上皮样肉瘤1例
| 作 者：舒建山, 陈柳青, 姜一化 |
| 单 位：武汉市第一医院 |
| 基金项目： |
| 摘 要： |
| 报告1例足底上皮样肉瘤。患者男，40岁。右脚足底结节2年，破溃4～5个月。皮肤科检查：右脚足底中央可见一5.0×2.0cm大、深约1cm的溃疡，周边少许肉芽样软组织生长。皮损组织病理检查：真皮中下部可见栅状肉芽肿样瘤细胞团块，中央有坏死表现，周边主要由上皮样细胞和梭形细胞组成，核分裂相增多。免疫组化染色显示肿瘤细胞表达细胞角蛋白（CK）、上皮膜抗原（EMA）、波形蛋白（vimentin）和CD34，而不表达CD31和S-100蛋白。患者的临床表现、组织病理改变及免疫组化染色均符合上皮样肉瘤的特点。 |
| 关键词：肉瘤，上皮样 |
A case of epithelioid sarcoma
| Author's Name: |
| Institution: |
| Abstract: |
| A case of epithelioid sarcoma was reported. A 40-year-old male patient presented with a gradually increasing, painful subcutaneous nodule on the right footplate of two years duration, and the nodule ulcerted four to five months ago. Physical examination showed an ulcer on the right footplate measuring 5.0×2.0 cm in width, 1 cm in depth. The ulcer was irregular with punched out and raised edges. The base was firm and the floor was covered with granulation tissue. Histopathologic examination revealed a typical annulare "granuloma-like" pattern of tumor cells surrounding a necroticfocus in mid and lower dermis, which composed mainly of diffuse sheets of epithelioid and spindle-shaped tumor cells. Mitotic was increased. Immunohistochemical studies showed that tumour cells were positively stained with cytokeratin(CK),epithelial membrane antigen (EMA), vimentin (vim) and CD34, but they were negative CD31 and S-100 protein. The clinical, pathological and immunohistochemical feature of this case supported the diagnosis of a conventional-type epithelioid sarcoma. |
| Keywords: sarcoma , epithelioid |
| 投稿时间：2008-11-18 |
|
|
|
|
|
